EGFR and neoplasm: We previously published the generation of such an OAd, ICO15K-cBTE (formerly virus “ICO15K-cBiTE,” renamed for trademark issues), which expresses a T cell engager formed by a single-chain variable fragment (scFv) against the human CD3 present in T cells fused to another scFv against human EGFR (present in tumor cells), thereby recruiting T cells to EGFR-positive tumors.25