JUN and nasopharyngeal carcinoma: Therefore, we hypothesized that NSCs in the early stages of development would not show abnormalities, whereas the NSCs in the adult brain would be impaired, as reported by Sung et al. In support of this hypothesis, Seo et al. [36] reported that NSCs derived from the lateral subventricular zone of NPC model mice showed enhanced c-Jun N-terminal kinase activity and DNA damage, which led to impairment of neurogenesis.