In contrast, Sarkar et al. found that stimulation of autophagy by nutrient starvation decreased p62/SQSTM1 and LC3-II/autophagosome levels in NPC patient-derived fibroblasts due to increased autophagic flux; furthermore, the excessive accumulation of p62/SQSTM1 in these cells was more clearly observed under normal culture with 10% FBS [30,41]. The gene discussed is SQSTM1; the disease is nasopharyngeal carcinoma.