Since the expression of several NRF2 response genes, such as glutathione peroxidase 4, Mn-superoxide dismutase, and heme oxygenase 1, was not promoted (data not shown), we conclude that the NRF2 pathway was not activated by the decrease in KEAP1, even in neurons differentiated from NPC patient-derived iPSCs. This evidence concerns the gene SOD2 and nasopharyngeal carcinoma.