As can be seen from Table 1,differential methylation of thegenes involved in the regulation of autoimmune responses(IL2RA, PTPN6, and SOCS1)[44, 47, 51] and CNSfunction (PADI2, CDKN2A,RUNX3, NEUROG1, and BDNF)[48, 50, 51] was detected inthe whole blood and various leukocyte populations of RRMS patients. This evidence concerns the gene NEUROG1 and relapsing-remitting multiple sclerosis.