MTHFR and inflammatory bowel disease: IBD is not associated with hereditary coagulation disorders predisposing tothrombosis.26,27 The prevalence of mutations in genes encodingfactor V Leiden, prothrombin G20210A, and methylenetetrahydrofolatereductase (MTHFR) is comparable in VTE patients with IBD andcontrols.26, , –29 Arecent genome-wide association study (GWAS) and whole-exome sequencing studyinvestigated and defined high genetic risk for VTE as the presence ofmultiple VTE genetic variants or at least one pathogenic variant.30 This high genetic risk was present in approximately one in seven IBDpatients.