Upregulation of mitochondrial fission by increased Drp1 expression was associated with an increased number of intrahepatic and distant metastasis in xenograft nude mice models.117 MFN1 downregulation was associated with increased vascular invasion and poorer prognosis in HCC tissue.115 Transition from an endothelial state to a mesenchymal state promotes tumour cell mobility and invasiveness, which is required for tumour metastasis. This evidence concerns the gene MFN1 and neoplasm.