Of these, the most common were found in DTA genes DNMT3A (20%) and TET2 (11%) (with the exception of ASXL1 mutations, which is expected given their low frequency in NPM1mut AML [16, 17]), plus others including IDH2 (14%), IDH1 (10%), NRAS (9%), FLT3-TKD (7%), PTPN11 (7%), SRSF2 (4%), and CEBPA (4%) (Fig. 1A). Here, PTPN11 is linked to acute myeloid leukemia.