In this study, we found for the first time that Rab1A promoted EMT progress in CRC cells evidenced by the facts that Rab1A knockdown increased E-cadherin expression and decreased Vimentin expression whereas Rab1A overexpression did the opposite, which is in accordance with the previous study in nasopharyngeal carcinoma11. Here, CDH1 is linked to colorectal carcinoma.