Among the peptides showing the most prominent increase in abundance in patients versus controls were fragments of B2M, albumin, and alpha-1-antitrypsin (A1AT), whereas fragments of collagen types (IV, V and VI), clusterin (CLU) and ubiquitin-associated protein 1-like (UBAP1L) were the peptides with the most decreased abundance levels in CRS (see Fig. 1c). This evidence concerns the gene B2M and congenital rubella syndrome.