However, a number of peptides/protein precursors, not highlighted previously in association to HF or CKD, such as peptides of PIGR, CD14, ANR17, COL4A2 COL4A4, COL6A5, ROBO1 and HUWE1 may be important players in the mechanisms of CRS. The gene discussed is HUWE1; the disease is congenital rubella syndrome.