Univariate analysis for risk factors of TM and NTM co-infection found that high level of AIGAs, WBC, N, HGB, IgG, IgM, IgA, serum globulin, ESR, and CRP and low level of CD4+T cells were taken as potential risk factors for TM and NTM co-infection. The gene discussed is CD40LG; the disease is coinfection.