Thus, we cultured three GBM primary cell lines in fibronectin-coated plates and found an increase in the mRNA levels of ODZ1 (Fig. 2a) and the protein expression of ODZ1 by immunofluorescence (Fig. 2b) that correlated with activation of Stat3 as determined by upregulation of the phosphorylated form of this transcription factor (Fig. 2c). This evidence concerns the gene TENM1 and glioblastoma.