CD8A and cancer: Such levels of immune infiltration lead to the production of tumor specific CD8 + T cells, which can clear cancer cells and generate systemic tumor specific immunity, resulting to a long-term anti-tumor memory response6,7.On the other hand, the microenvironment of cold tumors has no infiltration of immune cells or is mainly infiltrated by suppressive regulatory cell subtypes (including regulatory T cells (Tregs), regulatory B cells (bregs) and Myeloid Suppressor Cells (MDSCs))8–10.