In terms of infarction thickness, a statistically significant protective effect in reversing transmural cardiac fibrosis after ischemia (PLLA: 76.5 ± 5.01%, IM: 66.1 ± 13.99%, PLLA-HA/ACE2: 47.1±6.64%) was observed, only when rhACE2 was administered by the patch we tested here (Fig. 7f). The gene discussed is ACE2; the disease is ischemia.