Using the same gene deletion approach, miR-106b~25 knockout mice show enhanced paroxysmal atrial fibrillation related to disruption of a paired-like homeodomain transcription factor 2 homeobox gene (Pitx2) driven mechanism that controls the expression of the miR-17~92 and miR-106b~25 clusters51. The gene discussed is PITX2; the disease is Paroxysmal atrial fibrillation.