Whether the reported ability of ABC-like cells to accumulate with age in adipose tissue in an IL-1-dependent manner62 could provide a ready depot of these cells and lower the threshold of TLR7 stimulation needed by these cells to acquire full pathogenic functions will be an important question to be addressed given the link between obesity and COVID-19 outcomes. Here, TLR7 is linked to obesity due to melanocortin 4 receptor deficiency.