IFNA1 and systemic lupus erythematosus: In line with the known upregulation of both Type I and Type II IFN signatures in SLE patients, female ABCs were enriched for IFNα and IFNγ responses and upregulated several IFN stimulated genes (ISGs) expressed in SLE PBMCs (Fig. 4b; Supplementary Fig. 4B)37.