However, recent study from 162 Korean patients with MSI-H GC demonstrated that the group with 5-FU-based adjuvant chemotherapy showed better overall and disease-free survival compared to the group with no adjuvant chemotherapy47, suggesting a possible role of a defective MMR pathway in the responsiveness of 5-FU-based adjuvant chemotherapy. The gene discussed is MRC1; the disease is gastric cancer.