When comparing whole-exome mutation profiles between the R and NR groups, we identified 11 exclusively mutated cancer-associated genes, including KIAA1549 (4/13), BRD3 (3/13), ZMYM2 (3/13), PDGFRA (3/13), ICE1 (3/13), and TRIM33 (3/13), in the R group, and BCL9 (4/11), HEY1 (3/11), FOXO3 (3/11), NCOR2 (3/11), and DDR2 (2/11), in the NR group (Fisher’s exact test, P < 0.1, Fig. 2a). Here, ICE1 is linked to cancer.