Obese-prediabetic cohort has greater plasma glucose, insulin, HbA1C and triglyceride concentrations, an index of insulin resistance (homeostasis model of insulin resistance [HOMA-IR])18, and intrahepatic triglyceride content, and lower plasma HDL-cholesterol concentrations than in the Obese-normal group (Table 1). The gene discussed is INS; the disease is Insulin resistance.