PIK3CA and Epstein-Barr virus infection: Nevertheless, in accordance with prior results (online supplemental figure S7D), a higher PI3K pathway mutation frequency was also observed in the EBV subtype in comparison with the GS and CIN subtypes, suggesting a latent interplay between EBV infections and the PI3K signaling pathway (online supplemental figure S9A and online supplemental table S11), which may partially explain the predominant increase of the TMEscore in EBV-infected patients (figure 3F and online supplemental figure S9B).