SOCS1 and cancer: DNA methylation guided the epigenetic regulation of genes, which was not limited in cancer cells but also immune cells and stromal cells, thereafter hypomethylation of specific genes could modify TME components and their interactions.65 Xiao et al have emphasized the contribution of the specific gene SOCS1 methylation of CAFs made in reprogramming the TME induced by PDAC cells.66 Similarly, our analysis of DNA methylation landscape highlighted another gene methylation, VAMP8, correlated with the TME and immune-activity-related pathways.