Compared with the control group, LVSP and + dp/dtmax in the CLP group diminished, while LVEDP and − dp/dtmax enhanced significantly, accompanied by the increase of serum cTnI and CK-MB in the rats after monitoring the cardiac function, which indicated that cardiac dysfunction occurred in the sepsis rat model (Fig. 3B–F, P < 0.001). The gene discussed is TNNI3; the disease is Sepsis.