HSP90 is also low in plasma-derived EVs of symptomatic SOD1G93A (41% less) and TDP-43Q331K mice (73% less) (Fig. 4e and f), suggesting that low levels of HSP90 in plasma EVs could characterize several forms of ALS, sporadic and genetic. This evidence concerns the gene HSP90AA1 and amyotrophic lateral sclerosis.