Changes were investigated in: (i) C9ORF72-ALS disease (H_C-RNAi versus C9_C-RNAi; tabs 1 & 4); C9ORF72-ALS neurons treated with SRSF1-RNAi (C9_C-RNAi versus C9_SRSF1-RNAi; tabs 2 & 5); healthy control neurons treated with SRSF1-RNAi (H_C-RNAi versus H_SRSF1-RNAi; tabs 3 & 6). This evidence concerns the gene SRSF1 and amyotrophic lateral sclerosis.