Strikingly, the nuclear export inhibition of C9ORF72 repeat transcripts led to expression changes for ∼250 human mRNAs involved in multiple disease pathways out of ∼2250 changes in C9ORF72-ALS patient-derived neurons, indicating that, while the neurodegenerative process is characterised by a large number of gene expression changes, a small proportion of transcript changes is sufficient to suppress the neurodegenerative process. The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.