These data show that, consistent with the RNA-seq investigation, C9ORF72-ALS motor neurons have an enhanced expression of KCNN subunits and that inhibiting the activity of these Ca2+-activated potassium channels, as in the SRSF1-RNAi intervention, decreases apoptosis and cell death, promoting in turn neuronal survival. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.