C9orf72 and amyotrophic lateral sclerosis: However, the SRSF1-RNAi-induced transcript changes in healthy and C9ORF72-ALS neurons do not overlap (Fig. 2d) reinforcing the concept that healthy control and C9-ALS transcriptomes are very diverse at a global level due to widespread alteration of RNA metabolism in the C9ORF72-ALS disease state.