On the other hand, the neuroprotective effects of the depletion of SRSF1 were investigated in either C9ORF72-ALS or healthy patient-derived neurons by comparing transcripts levels in each cell type treated with control-RNAi and SRSF1-RNAi (C9-treated and H-treated groups respectively). Here, SRSF1 is linked to amyotrophic lateral sclerosis.