Neurons derived from induced neural progenitor cells reprogrammed from the fibroblasts of three different ALS patients harbouring C9ORF72-repeat expansion mutations (C9ORF72-ALS) and three healthy controls (Table 1) were treated with lentivirus expressing either scrambled control-RNAi (C-RNAi) or SRSF1-RNAi (ΔSRSF1) prior to nuclear and cytoplasmic fractionation in the same conditions and cell lines previously used to show that partial depletion of SRSF1 confers neuroprotection [12]. The gene discussed is SRSF1; the disease is amyotrophic lateral sclerosis.