SRSF1 and amyotrophic lateral sclerosis: A multidimensional scale analysis of the 24 identified transcriptomes (whole-cell and cytoplasmic triplicates from healthy and C9ORF72-ALS neurons treated with control- or SRSF1-RNAi lentivirus) shows that the partial depletion of SRSF1 does not overall disrupt the transcriptomes, with maintenance of the genetic variability between individuals (Fig. 2a).