C9 and amyotrophic lateral sclerosis: Thus, comparing transcript levels in C9ORF72-ALS neurons treated with either control-RNAi or SRSF1-RNAi lentivirus (C9-treated group) identified that a total of 362 RNA changes (351 DEGs; < 1% of the transcriptome comprising transcripts from ∼42,500 coding and non-coding genes) is implicated in the neuroprotection conferred by the partial depletion of SRSF1 (Fig. 2b-c, Table S5).