Using qRT-PCR assays, we further experimentally validated that thioredoxin (DHD), the most downregulated transcript in C9ORF72-ALS Drosophila, and the sodium-dependent nutrient aminoacid transporter NAAT1 in the ion transport pathway, exhibit reduced mRNA expression levels in disease while they are upregulated to normal levels upon SRSF1 depletion (Fig. 4c) in agreement with the computed DEG lists (Table S10, C9-disease and C9-treated). Here, SRSF1 is linked to amyotrophic lateral sclerosis.