Bufalin can also upregulate the expression of apoptotic proteins such as cleaved caspase 3 and poly(ADP ribose) polymerase, downregulate the expression of telomerase reverse transcriptase, induce apoptosis of glioma-like stem cells, and increase the sensitivity of glioma cells to temozolomide [16]. The gene discussed is CASP3; the disease is glioma.