In addition, the vast majority of studies have focused on the Wnt/ROR signaling and its influence on tumor cell function starting with two receptor tyrosine kinase-like orphan receptors (RORs), ROR1 and ROR2 with the activation of non-canonical Wnt signaling responses triggered by binding of Wnt5A ligand [25, 27]. Here, WNT5A is linked to neoplasm.