Recent findings have suggested the role of Wnt5A/ROR1 signaling in the progression of TNBC tumor cells through the phosphorylation of ROR1 by several kinases which results in the inhibition of anti-apoptotic pathways and activation of pro-survival signalings, such as Wnt/PCP, MAPK/ERK, PI3K/Akt/mTOR, TGF-β/SMAD and NF-κB. This evidence concerns the gene AKT1 and neoplasm.