Guo et al. [33] found that the expression of m6A and its regulatory factor HNRNPA2B1 was significantly increased in ESCC tissues, and the high expression of HNRNPA2B1 was positively correlated with tumor diameter and lymph node metastasis of ESCC. The gene discussed is HNRNPA2B1; the disease is esophageal squamous cell carcinoma.