Additionally, TKT exerted an inhibitory effect on STAT3-S727 phosphorylation and an activator effect on STAT3-Y705 phosphorylation in breast cancer, which rescued HDGF inhibition- suppressed the survival fraction and cell proliferation after I.R. These observations present a novel molecular link between HDGF, STAT3 phosphorylation, and TKT in breast cancer. This evidence concerns the gene STAT3 and breast cancer.