CLRN1 and retinitis pigmentosa 1: The phenotypes of USH1 patients include congenital severe-to-profound deafness, vestibular areflexia, and onset of retinitis pigmentosa (RP) within the first decade of life; USH2 manifests as moderate-to-severe hearing loss, normal vestibular function, and onset of RP within the second decade of life; and USH3 is characterized by hearing loss, vestibular dysfunction, and onset of progressive, sporadic, and variable RP [2].