STAT3 and Familial prostate cancer: Previous study suggested 6-P and its derivative 6-G had the ability to reduce the viability of human promyelocytic leukemia HL-60 cell and induce tumor cell apoptosis, indicating 6-P possessed potential cytotoxic activity.[15] By decreasing STAT3 and inactivating NF-κB signaling, 6-P significantly reduced survival of prostate cancer cells [21].