Patients receiving chemotherapy followed by Trastuzumab had a lower ovarian blood flow reduction than those receiving chemotherapy alone, according to Ben-Aharon et al. Besides, the use of Trastuzumab was shown, by a cross-sectional study, to be associated with elevated AMH in breast cancer survivors with normal menstruation [40], which was confirmed by a recent prospective observational study on premenopausal women with breast cancer who had undergone chemotherapy that patients receiving Trastuzumab had higher levels of AMH than those who did not [8]. The gene discussed is AMH; the disease is breast carcinoma.