To determine whether LFPRLR SMO affected the ability of peripheral Tregs (i.e. those not within the tumor) to suppress effector cell proliferation, we treated non-tumor bearing animals (Foxp3+EGFP Balb/c mice) for up to 5 months with Control SMO or LFPRLR SMO and then isolated splenocytes. This evidence concerns the gene FOXP3 and neoplasm.