To investigate whether the loss of ability to promote a mesenchymal phenotype indeed came from knockdown of the LFPRLR in Tregs themselves, we isolated tumor Tregs from untreated Foxp3+EGFP Balb/c mice and ex vivo treated with 1 μM Control SMO or LFPRLR SMO for 48 h. The gene discussed is FOXP3; the disease is neoplasm.