CLOCK and metabolic syndrome: Considering the overwhelming integration of the molecular circadian clock in gene expression and the fact that the circadian clock takes environmental cues (light, food) to synchronize gene expression, it would be expected that conditions that interfere with regular environmental or hormonal inputs would have serious pathological consequences, including metabolic syndrome, psychological problems, and cancer (9, 10, 11, 12, 13, 14, 27, 28, 29, 30, 31, 32, 33).