The protective role of TLR7 and type I IFNs in life-threatening COVID-19 has been documented based on the clinical outcome of patients with inborn errors in type I IFN immunity, producing blocking autoantibodies against different types of type I IFNs (5, 6) or expressing loss-of-function variants of TLR7 (34). Here, TLR7 is linked to COVID-19.