PIK3CA and colorectal carcinoma: Additionally, lentivirus-mediated downregulation of ABHD11-AS1 was found to inhibit CRC cell proliferation, invasion and migration by down-regulating the integrin subunit alpha (ITGA)5/focal adhesion kinase (Fak)/phosphoinositide 3 kinase (PI3K)/Akt pathway, both in vivo and in vitro.