To explore whether sh-ABHD11-AS1 exerted its function through regulating the ITGA5/Fak/PI3K/Akt signaling pathway in CRC, we transfected HCT116 and SW480 cells with sh-ABHD11-AS1 lentiviruses alone or in combination with ITGA5 lentiviruses. The gene discussed is PIK3CA; the disease is colorectal carcinoma.