A study indicated that the Crohn’s disease (CD) susceptibility gene ATG16L1 was phenocopied in mice infected with murine norovirus.63–65 Meanwhile, we have previously demonstrated that VDR transcriptionally regulates ATG16L1, and VDR status may be a determinant of Inflammatory Bowel Disease (IBD) risk through its actions on ATG16L1. Here, ATG16L1 is linked to Crohn disease.