DLL4 and glioblastoma: ESCs-EVs carry various cargoes including miRNAs (miR-291, -294 and -295) and proteins (heat shock protein 90 (HSP90), delta like canonical Notch ligand 4 (DLL4), stress inducible protein (STI1), and Wnt-10b), and these cargoes cause cardiac regeneration, inhibition of glioblastoma growth, and retinal regeneration (Kanellopoulou et al., 2015; Khan et al., 2015; Cruz et al., 2018a; Peng et al., 2018; Wiklander et al., 2019; Zhu et al., 2019).