In a recent follow-up study, the same group demonstrated that adipocyte–specific Tmem120a knockout mice cause disruption of fat-specific genome organization and yield a latent lipodystrophy pathology similar to lamin-linked human familial partial lipodystrophy type 2 (FPLD2) (Czapiewski et al., 2021). Here, TMEM120A is linked to familial partial lipodystrophy, Dunnigan type.