Increased expression of CDC42 is observed in several cancers, including breast and colorectal cancer (Fritz et al., 1999; Gómez Del Pulgar et al., 2008), and in melanoma, lung and testicular cancer, increased expression is associated with poor outcome (Kamai et al., 2004; Liu et al., 2009; Tucci et al., 2007). Here, CDC42 is linked to melanoma.