The RIP1 inhibitor Nec‐1 is a specific necroptosis inhibitor and effectively inhibits RIP1‐induced RIP3 activation, which has been shown to rescue cell death and provide neuroprotection in neurodegenerative diseases, include ischaemic stroke, TBI, spinal cord injury (SCI), subarachnoid haemorrhage (SAH) and intracerebral haemorrhage.39, 40, 41, 42. Here, PCSK1 is linked to neurodegenerative disease.