In a hydrocephalus mouse model, Nec‐1 and GSK872 reduce necrotic cell death, effectively inhibit the phosphorylation of RIP3 and MLKL, and reduce the levels of inflammatory factors such as IL‐1β, IL‐6 and TNF‐α in the cortex and hippocampus. This evidence concerns the gene PCSK1 and Hydrocephalus.