Taken together, these data indicate that Nec‐1 and GSK872 have certain neuroprotective effects after hydrocephalus, such as anti‐inflammatory effects, but some of the effects of blocking necroptosis on behaviour appear to be relatively minor, suggesting that necroptosis is perhaps not a major contributor to the impact of hydrocephalus on behaviour. Here, PCSK1 is linked to Hydrocephalus.