AKR1B10 and neoplasm: Research of breast cancer tissues and adjacent tissues performed by Li et al. has revealed that the expression of AKR1B10 in breast cancer tissues is overtly increased and positively correlated with tumor size and metastasis, and the overexpression of AKR1B10 promotes the proliferation and invasion of breast cancer cells, and its mechanism may be related to the activation of the ERK signaling pathway [20].