NFE2L2 and hydrops fetalis: Nrf2, an essential regulator in maintaining oxidative-antioxidant balance, is transferred into the nucleus combined with ARE as HF occurs (Figures 4(a) and 4(b), P < 0.05); as a result, the release of its downstream antioxidant molecules, HO-1 and Trx1, was stimulated simultaneously (Figure 4(c), P < 0.05).