STAT3 and glioblastoma: In a recent study, Fan et al. (2021) identified a novel mechanism through which procaine can impair the survival and self-renewal of the malignant glioblastoma stem cells, suggesting that local anesthetics may weaken zinc finger Asp-His-His-Cys-type palmitoyltransferase 15 (ZDHHC15) transcripts and decrease glycoprotein 130 (GP130) palmitoylation levels and membrane localization, thus, inhibiting the activation of interleukin-1 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling [41].