The top 5 miRNAs implicated in IBD included miR-148a (1st in all microRNA), miR-27b (15th), miR-152 (48th), miR-10174-3p (49th) and miR-182 (62th), which referred to the NOD, TLR4 and T cell receptor signaling pathways (Figure S2). This evidence concerns the gene TLR4 and inflammatory bowel disease.