In control P1 glioma cells (expressing a scramble nonsense shRNA/“scr-shRNA”) NLGN3 potently induced phosphorylation of Akt, Erk1/2 and S6K, whereas signaling was almost blocked in P1 glioma cells transduced with Gαi1/3 DshRNA (Figure 3A). Here, MAPK3 is linked to central nervous system cancer.