RUNX2 and neoplasm: While Lrp5-overexpressing CM elevated the level of CD95, an apoptosis-linked gene, in EO771 cells, Wnt1- and Fzd7-overexpressing CM decreased the level of CD95 and did not affect the levels of MMP9, Runx2, and Snail in EO771 tumor cells (Figure S10C&D).