The decision phase of apoptosis is mainly regulated by the Bcl2 family that is composed of antiapoptotic (i.e. Bcl2, Bcl-XL, Mcl-1, etc.)and proapoptotic (i.e. Bak, Bax, Bad, Bim, Bid, PUMA, etc.)members, and mediates chemo- and radioresistance in human lung cancers 9, 10. The gene discussed is BCL2; the disease is lung cancer.