As inflammatory cells under optic neuritis conditions, including microglial cells, astrocytes and T cells 50, 51, GFAP+ astrocytes and Iba1+ microglia displayed a hypertrophy morphology, and the density of microglia and intensity of GFAP were increased in YAPGFAP-CKO EAE mice, compared with that in YAPf/f EAE mice (Figure 3C-E). This evidence concerns the gene GFAP and optic neuritis.