GHR and obesity disorder: To evaluate the role of hepatic GHR in metabolic regulation, we first determined the mRNA expression of GHR in the liver of obese subjects, which were collected from a cohort of age-matched healthy male subjects (BMI: 20.96 ± 3.41 kg/m2) and patients with obesity (BMI: 41.84 ± 4.89 kg/m2) (Table S1).