What needs illustration is that mice with systemic insulin resistance display not only elevated circulating RBP4 levels but also attenuated renal clearance of RBP4, which is associated with the circulating level of transthyretin (TTR)-RBP4 formation that may reduce the glomerular filtration and renal catabolism of RBP4 10, 18, 19. This evidence concerns the gene RBP4 and Insulin resistance.