FOXC1 and breast carcinoma: Among the transcription factors upregulated by BRCA1 deficiency, overexpression of these EMT-TF induces EMT, and knockdown of SLUG, FOXC1, or FOXC2 in either BRCA1 mutant (SUM149 or SUM1315) or BRCA1 deficient (MDA-MB-231) breast cancer cell lines promotes expression of luminal and epithelial markers in vitro5, 21.