Loss of function of BRCA1 in breast cancer cells enhances the expression of several EMT inducing transcription factors (EMT-TFs) including SLUG 5, TWIST 20, FOXC1/C2 21, and inversely reduces the expression of a few of the EMT suppressing TFs, such as FOXA1 22, 23, FOXO3 24, 25. This evidence concerns the gene FOXO3 and breast carcinoma.