BRCA1 and breast cancer: We transduced p18-/-;Brca1MGKO tumor cells with pBabe-Empty and pBabe-Gata3 respectively, and found that ectopic Gata3 restored expression of Cdh1, a target of Gata3, but inhibited expression of Vim and EMT-TFs including Slug, Snail, and Twist1 (Figure 6A, B), which was stimulated by loss of Brca1 in mammary tumors (Figure 1A, Figure S1).