SLC5A7 and stroke disorder: These findings confirmed that early intervention promoted the cellular uptake of MPC-n(IVIg) that could be attributed to the decreased expression of ChT1 in endothelial cells after reperfusion, and indicated that the early administration of MPC-n(IVIg) enhanced the BBB penetration and facilitated the selective accumulation of IVIg in ischemic areas, thereby preventing the progression of stroke-induced damage.