The contrary report of Grubmüller et al., who found PSMA-TV reduction to be associated with longer OS, might be partly explained by the more advanced cancer stages in our cohort (median LDH = 282 vs. 189 U/L; median PSA 146 vs. 61 ng/mL), which could correlate with a larger fraction of patients who show low PSMA expression 15. The gene discussed is FOLH1; the disease is cancer.