By means of PCR and ELISA methods, our data provided experimental evidence that the level of VEGF-A was upregulated in the serum of rats intoxicated with HAPNPs and this could be one of the mechanisms by which HAPNPs restricts aneurysm growth, while the coadministration of CsNPs and/or CurNPs markedly reduced the imposing elevation in these biomarkers. This evidence concerns the gene VEGFA and aneurysm.