To the best of our knowledge, no previous work has been performed to evaluate protease expression in WM3682 cells, but a screen of the Broad Institute Cancer Cell Line Encyclopedia (CCLE) mRNA expression database revealed that MMP1 is highly expressed in most melanoma cell lines, suggesting that it could also be expressed in the WM3682 cell line and could therefore be involved in the cleavage process of PAR1 at a non-canonical cleavage site, between residues D39 and P4026. Here, MMP1 is linked to melanoma.